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Bridge PTS

Home
Our Company
About
Why Bridge PTS?
Getting Started
Collaborators
Licenses
BRIDGE PTS Cited Publications
Services
Wound Healing
Infection Control & Biofilms
Customized Surgical Work
Our Facility
Posters
Events
Blog
Contact Us
Search
  • Biofilm & Microbiology Testing
  • Rodent Lung Infection Animal Model
  • Rodent Implantable Biofilm Coated Devices
  • Rabbit Foley Catheter/Urinary Infection
  • Minimum Inhibitory Concentration (MIC) / Minimum Bactericidal Concentration (MBC)
  • Time Kill (TK)
  • Zone of Clearance/Inhibition (ZOC/ZOI)
  • Simple (Single Species) Biofilms
  • Complex (Multi-Species) Biofilms
  • Live-Dead Staining
  • Electron Microscopy
  • Tensile Testing (BF)
  • Rabbit Peritoneal Implant Model
  • Rabbit Vaginal Mucosal Irritation Model

Complex (Multi-Species) Biofilms

  • Duration of study – 6 days

  • Lead time – 2 weeks

  • Standard results – Microbiology


Model Utility:

This in vitro test utilized the Modified Robbins Device (MRD) to stimulate the growth of bacteria in a biofilm (cessile) state. The MRD works by using a flow-through system of extremely dilute growth media to encourage bacteria into the biofilm phenotype. Once in this state, it is possible to test surfaces for their ability to prevent attachment or growth of biofilm bacteria and to evaluate the activity of antimicrobial/anti-biofilm actives to destroy existing biofilm colonies.

 

How The MRD works:

Actual Biofilm Device Set Up (note: In actual operation media flask would be immersed in a heated water bath)

MRD sits in a heated Aluminum block

Secondary Device for Antimicrobial (Anti-biofilm) Solution Testing

 

References:

  1. Dasgupta MK, Larabie M, Lam K, Bettcher KB, Tyrrell DL, Costerton JW. Growth of bacterial biofilms on Tenckhoff catheter discs in vitro after simulated touch contamination of the Y-connecting set in continuous ambulatory peritoneal dialysis. Am J Nephrol. 1990;10(5):353-8.


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BRIDGE PTS, Inc., San Antonio, TX 78217, P: 210-532-7344