New BRIDGE PTS Record!

Somebody get the “Guiness Book” people on the phone!

It is with enormous pride that I announce a milestone for BRIDGE PTS. Last week our company, working with two teams of surgeons and engineers, completed 46 larger animal surgical procedures in only 6 days! By my quick calculations, the total number of “person-hours” was greater than 1,100 over that 6-day time-frame!

Phew!

As with every mountain we climb, we only have a moment to enjoy the view and the feeling of accomplishment before we start off on the next adventure. But what a view we have today!

Congratulations to all involved! Well done!!

Paul

BRIDGE PTS at SURF 2018!

Hello Everyone!  This is just a quick update to let everyone know that BRIDGE PTS is going to be at the San Antonio Military Health System & Universities Research Forum on June 28 and 29. 

http://research.utsa.edu/surf/

We would love to talk with you! Come on by and say hello, and if there are other meetings that you would like to see BRIDGE PTS attend please let us know.

Until next time,

Joe K.

Paul.Attar@bridgepts.com

210-532-7344

Stable Biofilms in Chronic Wounds

 Once again, I am back and today I would like to revisit a topic I posted about last time.  In my last post I wrote about the porcine chronic wound healing model that we have been developing here at BRIDGE PTS.  In that last post, I mentioned that we were able to create a stable biofilm infection in the chronic wounds, but I did not present any data to that effect.

So, this time around, I would like to share with you a poster that was just recently presented at the Symposium on Advanced Wound Care in Charlotte, NC.  In the study, we showed that after at least 13 days, the wounds that were the most delayed in their healing also had the highest total bioburden.   To our surprise, we did not see any cytotoxic activity from the glutaraldehyde treated wounds.  On day 13, the recovered staphylococcus reached 5 log CFUs per gram, a reduction from 7 log CFUs on day 4, while the pseudomonas reached >8 log CFUs on day 13. 

The study presented in Charlotte also tested different crosslinking chemicals to evaluate their ability to delay healing in wounds compared to glutaraldehyde.  Three additional chemicals were tested (Ribose, N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (EDC), and Genipin), but the only chemical to delay healing on par with glutaraldehyde was EDC while maintaining a stable and recoverable biofilm.

For more details, please look at the poster that I have linked below from the meeting in Charlotte, or contact Dr. Paul Attar who would be delighted to discuss the various models we can offer at BRIDGE PTS. 

Do you have a product that is designed to help speed the recovery of infected chronic wounds? Let us help you test your product. 

https://static1.squarespace.com/static/58f4d97917bffcda49811084/t/5aeb3a7c562fa72a39cc1b57/1525365377478/HWC-1446.pdf

Until next time,

Joe K.

Paul.Attar@bridgepts.com

210-532-7344

 

New Delayed Healing Model!

Hello everyone, I am back with more exciting news from BRIDGE PTS.  Over the past 2 years we have been working to develop and refine a novel porcine chronic wound healing model, and we are happy to say that we have succeeded!

The model works by creating the desired wound, then treating the wound with a chemical crosslinker to create an accelerated aging phenotype in the wound bed.  Our research shows that these artificially aged wounds increases the time to full closure of the wounds to more than 70 days! Perhaps even more importantly, our studies have shown that the chronic wounds can be rescued through mechanical debridement -- the standard of care in human patients.  We can create stable, biofilm infections in these wounds with at least two clinically-relevant bacteria (Staph and Pseudomonas) and research continues in our laboratory to understand and characterize the effects of currently utilized therapies to best understand how this model can be used to evaluate new technologies in development.

                For more details please take a look at the poster that was presented at the 2017 Wound Healing Society meeting in San Diego (link below), or feel free to contact Dr. Paul Attar who would be happy to discuss our new delayed healing model and any of the other models we use here at BRIDGE PTS.

2017 WHS Delayed Healing Poster

Do you have a product or technique you want to apply to chronic wounds?  Contact us and let us help you create the studies you need to properly test your products.  

Until next time,

Joe K.

Paul.Attar@bridgepts.com

210-532-7344

Expanded Animal Housing!

Hello all and Happy New Year! I am back with another exciting development here at BRIDGE PTS.  Over the past few months we have been working to our animal holding capacity within our main research facility at Brooks City Base.  To accomplish this task, we have renovated two of our large animal holding rooms into high density configurations. 

20180109_091036.jpg
Research Barn 1.jpg

With these new rooms we have increased our large animal holding capacity at our research facility to a new total of 60!   Combining both the high density caging with our newly constructed Research Barn (capacity of 100 large animals) opens up the opportunity for us to be able to accommodate both larger studies as well as more studies at one time.

Please continue to reach out to us for all of your research needs!

– Joe K.

Paul.Attar@bridgepts.com

210-532-7344

AAALAC Accreditation!

Hi Everyone!

I stole Joe K’s keyboard so that I could write this new and exciting update about BRIDGE PTS. Today, we received our letter from AAALAC affirming our new accreditation status! This new accreditation is a proud moment for our company and is a clear reflection of both the continuing maturation of our business and the technical excellence of staff.

I want to take this moment to thank all our employees and contractors. It is a direct result of their hard work and dedication that have helped us reach this important goal!

More updates are coming soon - - so keep any eye out for Joe’s next posts. Rumor has it he’s working on some pretty big announcements!

Warmest regards to you all!

Paul Attar

AAALAC Letter Pic.JPG

New Research Barn!

With this being the inaugural post on BRIDGE PTS’ shiny and new blog I will start by introducing myself.  My name is Joe K., and I am a technician here at BRIDGE PTS. 

I am excited to announce a big development for BRIDGE PTS and our customers.  We have broken ground and are well underway in the construction of our new Research Barn.  The facility, expected to be completed in September of this year, is a brand new 10 stall barn that will greatly expand our large animal holding capacity from 30 to 70!   We will be able to extend the length of chronic studies, as well as facilitate multi-stage studies with long time periods in between stages.  The possible uses for the new facility are very exciting for us here at BRIDGE PTS.

                I hope that this new and exciting development has grabbed your attention.  Has it spawned new project ideas for you, or opened new opportunities for already existing projects?  Drop us a line and let us know what you think.  I hope to hear from you soon.            

-  Joe K.

Paul.Attar@bridgepts.com

210-532-7344