Anatomical Effects in the Development of a Delayed Wound Healing Model
ACell, Inc. currently markets multiple configurations of its Urinary Bladder Matrix (UBM-ECM) product, called MatriStem®. This material is derived from the decellularized basement membrane and tunica propria layers of the porcine bladder and consists of extracellular matrix proteins including collagens, glycosaminoglycans, and growth factors, which provide both a structural and biological framework for tissue healing [1, 2, 3].
Although the mechanism of action behind ECM-mediated constructive remodeling is not yet fully understood, it has been hypothesized that these ECM-derived biomaterials act as in situ bioactive regenerative templates, serving as substrates for progenitor cell infiltration and differentiation. The ECM biomaterial can be considered a concentrated version of the body's own natural scaffold that occurs after injury. The body is hypothesized to act as a bioreactor, providing additional site-specific biomechanical and biochemical cues that guide cell differentiation. Studies have demonstrated the chemo-attractive effects of UBM-ECM biomaterial breakdown products on progenitor cells .
In June 2012, ACell, Inc. received a Space Medicine and Related Technologies Commercialization Assistance Program (SMARTCAP) award from the National Space Biomedical Research Institute (NSBRI) to develop a novel MatriStem UBM gel formulation, which can be easily administered to wounds in space. The development of a novel gel formulation of MatriStem UBM technology that preserves the bioactivity and vulnerary properties of the biomaterial would provide astronauts with a powerful new tool to combat lacerations and abrasions incurred during flight missions. Although existing MatriStem products have the potential to improve healing in space, current dressing configurations would be difficult to administer in low gravity and maintain position under high activity levels. Promising prototypes have been developed (Figure 1) and are undergoing continuing characterization. In order to mimic the delayed healing in space, a novel model of ischemic wound healing in rats has been developed which will be used to test the in vivo efficacy of the gel prototypes.