Stable Biofilms in Chronic Wounds

 Once again, I am back and today I would like to revisit a topic I posted about last time.  In my last post I wrote about the porcine chronic wound healing model that we have been developing here at BRIDGE PTS.  In that last post, I mentioned that we were able to create a stable biofilm infection in the chronic wounds, but I did not present any data to that effect.

So, this time around, I would like to share with you a poster that was just recently presented at the Symposium on Advanced Wound Care in Charlotte, NC.  In the study, we showed that after at least 13 days, the wounds that were the most delayed in their healing also had the highest total bioburden.   To our surprise, we did not see any cytotoxic activity from the glutaraldehyde treated wounds.  On day 13, the recovered staphylococcus reached 5 log CFUs per gram, a reduction from 7 log CFUs on day 4, while the pseudomonas reached >8 log CFUs on day 13. 

The study presented in Charlotte also tested different crosslinking chemicals to evaluate their ability to delay healing in wounds compared to glutaraldehyde.  Three additional chemicals were tested (Ribose, N-(3-Dimethylaminopropyl)-Nā€™-ethylcarbodiimide (EDC), and Genipin), but the only chemical to delay healing on par with glutaraldehyde was EDC while maintaining a stable and recoverable biofilm.

For more details, please look at the poster that I have linked below from the meeting in Charlotte, or contact Dr. Paul Attar who would be delighted to discuss the various models we can offer at BRIDGE PTS. 

Do you have a product that is designed to help speed the recovery of infected chronic wounds? Let us help you test your product.

Until next time,

Joe K.