Development of a Porcine Model of Delayed Wound Healing
- Chronic wounds do not proceed through the normal phases of wound healing and often stall in the inflammatory phase.
- Chronic wounds affect over 6 million people in the US due to slower wound healing associated with aged skin, impaired blood circulation, diabetes and other comorbidities .
- Rodent or porcine diabetic models are frequently used to model chronic wounds, such as diabetic ulcers, but these models are unable to fully replicate the clinical complications, especially chronicity of the wound.
- In this study, we developed a model to mimic healing impairment that is caused by glycosylation of collagen resulting from extended exposure to hyperglycemia .